Retinoblastoma Loss in Cancer: Casting a Wider Net

Casting a Wider Net: Engaging Community Health Worker Clients and Their Families in Cancer Prevention

Engaging family members in an intervention to prevent breast and cervical cancer can be a way to reach underserved women; however, little is known about whether family member recruitment reaches at-risk women. This study reports the kin relationship and risk characteristics of family members who chose to participate in the Kin Keeper(SM) cancer prevention intervention, delivered by community he...

Casting a wider fish net on animal models in neuropsychiatric research

Neuropsychiatric disorders, such as schizophrenia, are associated with abnormal brain development. In this review, we discuss how studying dimensional components of these disorders, or endophenotypes, in a wider range of animal models will deepen our understanding of how interactions between biological and environmental factors alter the trajectory of neurodevelopment leading to aberrant behavi...

Meat consumption trends and health: casting a wider risk assessment net.

Humans come from a long line of meat-eaters. For much of the past two million years our hominid forebears have been evolving from scavenging to systematic hunting. This trend was intimately coupled with the evolution of the human brain, which now is much larger and more complex than was the brain of our mostly vegetarian australopithecine ancestors. In many hunter-gatherer communities meat beca...

Casting a wider net: whole-cell assays to capture varied and biased signaling.

The observation of complex receptor behaviors has shown how ligands can have multiple efficacies and can also differentially stimulate certain cellular signaling pathways over others (i.e., biased signaling). Conventional pharmacological assays (usually proximal to the receptor) will detect ligands that produce the signal defined by the assay (i.e., Ca²⁺, cAMP, and others) but otherwise may mis...

Molecular Pharmacology: Perspective Casting a Wider Net: Whole Cell Assays to Capture Varied and Biased Signaling